**The AI Revolution Continues: 49 US Startups That Raised $100M or More in 2025**
2025 has been a wild ride for the AI industry, with a whopping 49 US startups raising funding rounds valued at $100 million or more. As we kick off 2026, it’s clear that the momentum is only going to keep building. From Elon Musk’s xAI to Sam Altman’s Merge Labs, some of the biggest names in tech are making waves in the AI space.
**December’s Big Winners**
* Mythic, a startup building power-efficient compute platforms, pulled in a $125 million venture round led by DCVC.
* Chai Discovery, which is revolutionizing biotech and drug discovery with AI, raised a $130 million Series B round valued at $1.2 billion.
* Fal, a generative media platform, raked in a $140 million Series D round led by Sequoia.
* Unconventional AI, a young startup rethinking the foundations of computing, raised a massive $475 million seed round led by Lightspeed and Andreessen Horowitz.
* 7AI, a cybersecurity AI broker builder, secured a $130 million Series A round led by Index Ventures.
**November’s Notable Deals**
* Genspark, an all-in-one AI workspace platform, raised a $275 million Series B round valued at $1.25 billion.
* Luma AI, which is changing the game with models for image and video creation, brought in a whopping $900 million Series C round valued at $4 billion.
* Anysphere, the maker of the viral vibe-coding platform Cursor, raised $2.3 billion in a funding round valued at $29.3 billion.
* Parallel, which builds net infrastructure for AI brokers, landed a $100 million Series A round co-led by Index Ventures and Kleiner Perkins.
* Hippocratic AI, a healthcare AI agent startup, raised a $126 million Series C round valued at $3.5 billion.
**October’s Big Guns**
* Fireworks AI, a platform for building AI functions using open-source models, raised a $250 million Series C round valued at $4 billion.
* Uniphore, an enterprise AI startup, brought in a $260 million Series F round valued at $2.5 billion.
**Other Standout Deals**
* Sesame, a voice AI firm, raised a $250 million Series B round co-led by Sequoia and Spark Capital.
* OpenEvidence, a medical AI chatbot platform, raised a $200 million Series C round valued at $6 billion.
* Lila Sciences, an AI infrastructure firm, brought in a $250 million Series C round valued at $2.5 billion.
* Celestial AI, a photonic fabric AI infrastructure startup, raised a $250 million Series C round valued at $2.5 billion.
* Together AI, an open-source generative AI and AI model growth infrastructure platform, raised a $305 million Series B round valued at $3.3 billion.
This post has been updated multiple times since its initial publication to reflect the latest developments in the AI startup space. Stay tuned for more updates on the exciting world of AI!
**Update History**
This piece was last updated on January 19, 2026.
